Nanoporous starch materials were successfully prepared by a sustainable synthetic process. In this method, some available economic cationic, anionic and nonionic templates like CTAB, SDS and Tween 80 in the presence of borax, as a green and low-cost cross-linker, were used to synthesize the desired cross-linked nanoporous starch in the aqueous phase at relatively low temperature. The obtained materials were characterized by SEM, FT-IR, TGA, DSC and N2 adsorption/desorption methods. While SEM analysis confirmed the porous nature of the materials, BET measurement showed that the materials can have a specific surface area of 65 m² g-1. Cross-linked nanoporous starch was found to be an efficient, inexpensive, easy to prepare, green adsorbent in the removal of methylene blue and methyl orange from wastewater. The synthesized material was found to be highly efficient in controlled adsorption and desorption of ciprofloxacin, which can be applied in drug delivery.

Herein we report the synthesis of some novel indeno[1,2-b]benzofuran derivatives by reaction of ninhydrin with cyclic 1,3-dicarbonyl compounds including cyclopentane-1,3-dione, cyclohexane-1,3-dione, dimedone, 4,4-dimethylcyclohexane-1,3-dione, meldrum's acid, barbituric acid, thiobarbituric acid, 1,3-dimethylbarbituric acid and indane-1,3-dione. We also used tetra-propylammonium bromide (TPAB) as an organocatalyst.

Abstract. A green approach for the synthesis of polyfunctionalized pyrrolo[2,3-d]pyrimidine derivatives was successfully achieved by a one-pot three-component reaction of arylglyoxals, 6-amino-1,3-dimethyluracil and barbituric acid derivatives in the presence of tetra-n-butylammonium bromide (TBAB) (5 mol%) as the catalyst in ethanol at 50 °C. This protocol has many advantages such as high yields (73-95%), green and simple procedure, short reaction times, easy work-up, mild reaction conditions and general applicability.

Resumen. Se describe el desarrollo de una ruta sintética sustentable para la preparación de derivados pirrolo[2,3-d]pirimidinas mediante una reacción de tres componentes en un matraz de arilglioxales, 6-amino-1,3-dimethyluracilo y derivados del ácido barbitúrico en presencia de bromuro de tetra-n-butilamonio (TBAB) (5% mol) como catalizador en etanol a 50 ºC. Este protocolo posee diversas ventajas, tales como elevados rendimientos (73-95%), procedimiento simple y sustentable, cortos tiempos de reacción, extracción sencilla, condiciones de reacción suaves y amplia aplicabilidad.

This study reports the reduction of α,β-unsaturated ketones 4a-g, formed by condensation of arylglyoxals 2a-g with 1,3-dimethylbarbituric acid (3) by L-cysteine (5) in the presence of phosphotungstic acid as a catalyst. This reaction leads to the formation of 5-[2-aryl-2-oxoethyl ]-1,3-dimethylpyrimidine-2,4,6-triones 6a-g, with no sign of any heterocyclic product formation. The structure of compound 6f was confirmed by X-ray crystallography.

An efficient method for the synthesis of 1-aryl-6,6-dimethyl-2-phenyl-6,7-dihydro-1H-indol-4(5H)-ones is achieved in two steps, using a three-component reaction of phenacyl bromide, dimedone and aniline derivatives in water-ethanol (1:1) under reflux conditions.

Uma série de seis derivados do propan-1-ol 2,2-disubistituído 3-[3,5-di-iso-propil-4-hydroxifenil] foi preparada para avaliação como moduladores alostéricos de receptores GABA B. A maior atividade (EC50 30 µM) encontrada na série foi para os análogos do dimetil, mas os compostos isopropilfenil foram, de maneira geral, mais fracos que os compostos t-butílicos. A metilação do grupo fenólico levou à uma perda de atividade.

A series of six 2,2-disubstituted 3-[3,5-di-iso-propyl-4-hydroxyphenyl]propan-1-ol derivatives have been prepared for evaluation as allosteric modulators of GABA B receptors. The activity (EC50 30 µM) was greatest for the dimethyl analogue, but the isopropylphenyl compounds were generally weaker than the corresponding t-butyl compounds. Methylation of the phenolic group led to loss of activity.

3-Arilaminoisoxazol-5(2H)-onas, substituídas no nitrogênio com grupos benzoxazol e benzotiazol, reagem com trietilamina em etanol, sob refluxo, fornecendo os correspondentes derivados indol e imidazobenzotiazol, respectivamente.

3-Arylaminoisoxazol-5(2H)-ones, substituted on nitrogen with benzoxazole and benzothiazole groups react with triethylamine in ethanol under reflux to afford the corresponding indole and imidazobenzothiazole derivatives, respectively.